منابع مشابه
Estradiol, TGF-β1 and hypoxia promote breast cancer stemness and EMT-mediated breast cancer migration.
Breast cancer is one of the most common cancer types among women, acting as a distinct cause of mortality, and has a high incidence of recurrence. External stimuli, including 17β-estradiol (E2), transforming growth factor (TGF)-β1 and hypoxia, may be important in breast cancer growth and metastasis. However, the effects of these stimuli on breast cancer stem cell (CSC) regulation have not been ...
متن کاملAPRIL and BAFF increase breast cancer cell stemness
Background: Recent advances in cancer immunology revealed immune-related properties of the cancer cell as a promising new therapeutic target. The two TNF superfamily members, APRIL and BAFF even though were primarily studied for their role in lymphocyte maturation, their presence in a number of normal and cancer solid tumors including breast cancer revealed an association with tumor growth and ...
متن کاملThe SRF-YAP-IL6 axis promotes breast cancer stemness
Fine regulation of differentiation and expansion of adult stem cells is required for the maintenance of tissue homeostasis. Deregulation toward expansion of adult stem cells is a common characteristic of poorly differentiated cancer and cancer stem cells. In this context, YAP (Yes associated protein) has gained considerable research attention as a critical mediator involved in promoting expansi...
متن کاملHypoxia regulates stemness of breast cancer MDA-MB-231 cells.
Human breast cancers include cancer stem cell populations as well as non-tumorigenic cancer cells. Breast cancer stem cells possess self-renewal capability and thus are the root cause of recurrence and metastasis of malignant tumors. Hypoxia is a fundamental pathological feature of solid tumor tissues and exerts a wide range of effects on the biological behavior of cancer cells. However, there ...
متن کاملReversing cancer stemness
lethality of malignant breast cancer in human patients. Although various targeted and non-targeted therapies can occasionally control the progress of breast cancer, a significant portion of patients develop resistance to chemotherapy and experience metastatic recurrence. The epithelial to mesenchymal transition (EMT), a key developmental program in embryogenesis, has been found to be closely in...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Molecular and Cellular Endocrinology
سال: 2014
ISSN: 0303-7207
DOI: 10.1016/j.mce.2013.03.024